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Acticlate
Acticlate (generic name: doxycycline hyclate) is an antibiotic used to treat a variety of bacterial infections, including acne, respiratory tract infections, urinary tract infections, and certain sexually transmitted infections (STIs). It belongs to the tetracycline class of antibiotics and works by inhibiting bacterial protein synthesis, effectively stopping bacterial growth. Acticlate is commonly prescribed for both acute infections and chronic conditions such as acne, where long-term use may be necessary.
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Frequently Asked Questions
How long does it take for Acticlate to work for acne?
It may take several weeks to see improvements in acne symptoms, so continue using the medication as prescribed.
Can I take Acticlate with food?
Yes, Acticlate can be taken with food to help reduce stomach upset. However, avoid taking it with dairy products, as calcium can interfere with its absorption.
What should I do if I miss a dose of Acticlate?
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses at the same time to make up for a missed one.
Is Acticlate safe to use during pregnancy?
No, Acticlate is not recommended during pregnancy due to the risk of harm to the developing fetus, including tooth discoloration and effects on bone growth.
Can I drink alcohol while taking Acticlate?
There is no direct interaction between alcohol and doxycycline, but alcohol can reduce your body’s ability to fight infection and may delay recovery. It’s best to limit alcohol consumption while on this medication.
Comprehensive Drug Guide
How Does Acticlate Work?
Acticlate works by inhibiting the synthesis of bacterial proteins. It does this by binding to the 30S ribosomal subunit in bacteria, preventing the production of proteins necessary for bacterial growth and reproduction. This action is bacteriostatic, meaning it stops bacteria from multiplying, allowing the body’s immune system to eliminate the infection. It is effective against a wide range of gram-positive and gram-negative bacteria, as well as certain atypical pathogens.
Common Dosages
- Tablets and capsules: 75 mg and 150 mg strengths
Typical Dosing
- For acne: The usual dose is 100 mg once or twice daily, depending on the severity of the condition.
- For bacterial infections: Dosing may vary depending on the type and severity of the infection, but typically 100 mg is taken every 12 hours on the first day, followed by 100 mg once daily.
- Always follow your healthcare provider’s dosing instructions, as they may adjust the dose based on your specific condition.
Typical Dosing
FDA Approved Indications
- Acne vulgaris
- Respiratory tract infections (such as pneumonia)
- Urinary tract infections
- Sexually transmitted infections (including chlamydia)
- Tick-borne diseases (such as Lyme disease and Rocky Mountain spotted fever)
Who Shouldn't Take Acticlate?
- Known hypersensitivity to doxycycline, tetracyclines, or any component of the formulation
- Pregnant women (due to the risk of harm to the developing fetus, particularly tooth discoloration)
- Children under 8 years of age, as it can cause permanent tooth discoloration and affect bone development
Advice From The Pharmacist
- Take Acticlate with a full glass of water to reduce the risk of esophageal irritation and ulceration.
- Avoid lying down immediately after taking the medication to prevent the risk of esophageal irritation.
- Avoid direct sunlight or artificial UV rays (such as tanning beds) while on this medication, as doxycycline can make your skin more sensitive to sunlight.
- Do not take antacids, calcium, or iron supplements within two hours of taking Acticlate, as these can reduce the effectiveness of the medication.
- Complete the full course of treatment even if symptoms improve to ensure the infection is fully cleared.
Side Effects of Acticlate
Common Side Effects
- Nausea and vomiting
- Diarrhea
- Sensitivity to sunlight (photosensitivity)
- Esophageal irritation or heartburn
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, difficulty breathing)
- Increased pressure inside the skull (intracranial hypertension)
- Severe headaches or blurred vision (indicative of intracranial hypertension)
Risks and Warnings of Acticlate
- Photosensitivity: Acticlate can increase your skin’s sensitivity to sunlight, leading to severe sunburns. Always use sunscreen and protective clothing when exposed to the sun.
- Esophageal Irritation: Taking Acticlate without enough water or lying down immediately after taking it may lead to severe irritation of the esophagus.
- Pregnancy and Children: Acticlate should be avoided in pregnant women and young children due to the risk of permanent tooth discoloration and effects on bone development.
Interactions with Acticlate
Common Drug Interactions
- Antacids: Medications containing aluminum, calcium, or magnesium can interfere with the absorption of Acticlate.
- Iron supplements: Taking iron supplements can reduce the absorption of Acticlate and make it less effective.
- Warfarin: Acticlate can enhance the anticoagulant effects of warfarin, increasing the risk of bleeding.
- Birth control pills: Doxycycline may reduce the effectiveness of oral contraceptives, so additional non-hormonal forms of contraception are recommended during treatment.
Alternatives to Acticlate
- Minocycline: Another tetracycline antibiotic used to treat acne and bacterial infections.
- Clindamycin: A topical or oral antibiotic commonly used for acne and bacterial infections.
- Azithromycin: An alternative antibiotic for those who cannot tolerate doxycycline, particularly for respiratory infections or STIs.
- Amoxicillin: A penicillin-class antibiotic often used to treat similar bacterial infections but with a different mechanism of action.
