You're not logged in. Please log in to earn stock or Bitcoin rewards on your prescription purchase.
ACAM2000
ACAM2000 is a live attenuated smallpox vaccine used for the prevention of smallpox infection. It contains the vaccinia virus, a virus closely related to the smallpox virus (variola virus), which stimulates the immune system to develop immunity against smallpox. ACAM2000 is primarily used for vaccination of military personnel, laboratory workers, and certain healthcare workers who may be at risk of exposure to the smallpox virus. It is also part of the national stockpile for use in the event of a bioterrorism threat involving smallpox.
Oops! We currently don’t have the pricing information for this drug.
But we're continually improving our service to help you save and earn rebates on your medications. If your drug isn't listed on NiHowdy, you can still present your NiHowdy savings card at the pharmacy. We'll work to secure any eligible rebates for that drug and pass the savings back to you retroactively.
Members have saved
$NaN
using our savings card for instant savings.
Don't pay full retail price and miss out on potential savings. Try it now—you have nothing to lose!
NaNM
worth of Satoshi has been rewarded to our members.
Everyone who signs up enjoys the benefits of earning FREE Bitcoin with every purchase.
Frequently Asked Questions
How effective is ACAM2000 in preventing smallpox?
ACAM2000 is highly effective in preventing smallpox when administered before exposure or within a few days after exposure. The vaccine induces a strong immune response that provides long-lasting protection.
How long does it take for ACAM2000 to work?
A successful vaccination, indicated by the formation of a pustule at the injection site (the "take"), usually occurs within 6 to 8 days after vaccination. This indicates that the vaccine is working and that immunity is developing.
Can ACAM2000 be used in an outbreak situation?
Yes, ACAM2000 is part of the national stockpile for use in the event of a smallpox outbreak or bioterrorism threat. It can be administered to individuals at risk of exposure during such events.
What should I do if I experience severe side effects after receiving ACAM2000?
If you experience severe side effects, such as chest pain, difficulty breathing, or a severe skin reaction, seek medical attention immediately. Inform your healthcare provider that you have recently received the smallpox vaccine.
Comprehensive Drug Guide
How Does ACAM2000 Work?
ACAM2000 works by introducing the vaccinia virus into the body, which triggers the immune system to produce antibodies and cellular responses against the virus. These immune responses are cross-protective against the smallpox virus, providing immunity. Since ACAM2000 is a live attenuated vaccine, it mimics a natural infection, leading to long-lasting immunity after a single dose.
Common Dosages
ACAM2000 is administered as a single dose of 0.0025 mL by percutaneous inoculation using a bifurcated needle. The vaccine is delivered via a series of punctures on the upper arm, typically 15 punctures for primary vaccination and 15 punctures for revaccination.
The typical dosing for ACAM2000 is:
Adults and Children: A single dose administered percutaneously. Revaccination may be required for continued protection in individuals at sustained risk of exposure, typically every 3 to 5 years.
Typical Dosing
FDA Approved Indications
ACAM2000 is FDA-approved for:
- Active immunization against smallpox in individuals at high risk of exposure to the smallpox virus, such as military personnel, laboratory workers handling orthopoxviruses, and healthcare providers involved in smallpox outbreak response.
Who Shouldn't Take ACAM2000?
ACAM2000 should not be used in individuals with:
- A history of severe allergic reactions to any component of the vaccine
- Immunodeficiency conditions, such as HIV/AIDS or cancer treatment, that weaken the immune system
- Eczema or other chronic skin conditions
- Pregnant or breastfeeding women
- Household contacts with any of the above conditions, as the live virus in the vaccine can be transmitted to others
Advice From The Pharmacist
Patients receiving ACAM2000 should:
- Understand that the vaccine involves a live virus and may cause a localized skin reaction (the "take") at the vaccination site. This reaction is expected and indicates that the vaccine is working.
- Keep the vaccination site covered with a sterile bandage to prevent the spread of the vaccinia virus to other parts of the body or to other people.
- Avoid close contact with individuals who are immunocompromised, pregnant, or have chronic skin conditions until the vaccination site has completely healed.
- Follow all post-vaccination care instructions provided by healthcare professionals, including how to care for the vaccination site and when to seek medical attention.
Side Effects of ACAM2000
Common Side Effects
Common side effects of ACAM2000 include:
- Redness, swelling, and itching at the injection site
- Fever
- Fatigue
- Headache
- Muscle aches
Uncommon/Severe Side Effects
Serious side effects may include:
- Myopericarditis (inflammation of the heart muscle and surrounding tissue)
- Eczema vaccinatum (severe skin reaction in individuals with eczema)
- Progressive vaccinia (severe and potentially life-threatening infection with vaccinia virus)
- Accidental inoculation of the virus to other parts of the body or to others
Risks and Warnings of ACAM2000
Major risks and warnings associated with ACAM2000 include:
- Myopericarditis: ACAM2000 has been associated with an increased risk of myopericarditis, particularly in young adult males. Patients should be monitored for signs of chest pain, shortness of breath, or other cardiac symptoms after vaccination.
- Transmission of Vaccinia Virus: The live vaccinia virus can be transmitted from the vaccination site to other parts of the body or to other people, especially those with weakened immune systems or skin conditions. Proper care of the vaccination site is essential to prevent this.
Severe Skin Reactions: Individuals with a history of eczema or other chronic skin conditions are at risk for severe skin reactions and should not receive the vaccine.
Interactions with ACAM2000
Common Drug Interactions
ACAM2000 may interact with:
- Immunosuppressive Drugs: Drugs that suppress the immune system (e.g., corticosteroids, chemotherapy) may reduce the effectiveness of the vaccine and increase the risk of severe side effects.
- Antiviral Medications: Medications that treat viral infections (e.g., cidofovir) may interfere with the efficacy of the vaccine.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential interactions.
Alternatives to ACAM2000
Alternative smallpox vaccines to ACAM2000 include:
- Jynneos (Imvamune/Imvanex): A newer, non-replicating smallpox and monkeypox vaccine that is safer for use in immunocompromised individuals and those with skin conditions.
- Dryvax: An older smallpox vaccine that has been replaced by ACAM2000 but may still be available in certain stockpiles.
