NiHowdy > Drug Classes > Monoclonal Antibodies

Browse Medications by Drug Class: Monoclonal Antibodies

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Updated Jan 24, 2025

•

Published Jan 15, 2025

Fact checked

What are Monoclonal Antibodies?

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to target specific antigens, such as proteins on the surface of cancer cells, viruses, or inflammatory mediators. These antibodies mimic the immune system's ability to fight infections and diseases by binding precisely to their targets and either neutralizing them or marking them for destruction. Monoclonal antibodies are widely used to treat conditions such as autoimmune diseases, cancers, and infectious diseases. A defining feature of mAbs is their specificity, which allows for targeted treatment with fewer off-target effects compared to traditional therapies. NiHowdy ensures patients have access to these life-changing treatments at affordable prices, improving outcomes for chronic and acute conditions.

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List of drugs in Monoclonal Antibodies

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Syfovre

Syfovre Information

Syfovre Pricing

Brief history about Monoclonal Antibodies?

The development of monoclonal antibodies began in the 1970s, when scientists Georges Kohler and Cesar Milstein developed a method for producing identical antibodies from a single B-cell clone, a breakthrough that earned them a Nobel Prize in 1984. The first FDA-approved monoclonal antibody, muromonab-CD3, was introduced in 1986 to prevent organ transplant rejection. Since then, advancements in genetic engineering have led to the development of humanized and fully human antibodies, significantly improving their safety and efficacy. Today, monoclonal antibodies are used to treat a wide range of conditions, including rheumatoid arthritis, cancers, and infectious diseases like COVID-19. NiHowdy makes accessing these advanced treatments simple and cost-effective for patients in need.

How do Monoclonal Antibodies work?

Monoclonal antibodies work by binding to specific targets, depending on their therapeutic purpose. Upon binding, they can block harmful processes, stimulate the immune system, or directly neutralize pathogens. ^ Anti-TNF-alpha Antibodies: Such as infliximab and adalimumab, bind to tumor necrosis factor-alpha (TNF-alpha), preventing inflammation in autoimmune diseases like rheumatoid arthritis and Crohn's disease. ^ Anti-PD-1/PD-L1 Antibodies: Such as pembrolizumab and nivolumab, enhance the immune response against cancer by preventing immune checkpoint suppression. ^ Anti-HER2 Antibodies: Such as trastuzumab, target the HER2 receptor on breast cancer cells, inhibiting their growth and signaling the immune system to destroy them. ^ Neutralizing Antibodies (Infectious Diseases): Such as sotrovimab for COVID-19, bind to viral spike proteins, preventing the virus from entering human cells. Monoclonal antibodies provide precision therapy by selectively targeting abnormal or harmful processes while sparing healthy tissues. NiHowdy ensures patients can access these specialized therapies affordably and conveniently.

What are Monoclonal Antibodies used to treat?

Autoimmune Diseases

Monoclonal antibodies targeting inflammatory mediators, such as infliximab for Crohn's disease and rituximab for rheumatoid arthritis, help reduce inflammation, prevent joint damage, and improve overall quality of life.

Cancer

Monoclonal antibodies such as trastuzumab for HER2-positive breast cancer and nivolumab for metastatic melanoma enhance the immune response against cancer cells or directly inhibit tumor growth. These therapies have revolutionized cancer treatment by offering targeted approaches with fewer systemic side effects.

Infectious Diseases

Neutralizing monoclonal antibodies, such as sotrovimab for COVID-19 and palivizumab for RSV (respiratory syncytial virus), are used to prevent or treat severe viral infections by blocking viral entry into human cells.

Organ Transplant Rejection

Monoclonal antibodies such as basiliximab are used to prevent acute organ transplant rejection by blocking immune responses that could lead to graft failure.

Ophthalmic Disorders

Monoclonal antibodies targeting vascular endothelial growth factor (VEGF), such as ranibizumab, are used to treat age-related macular degeneration (AMD) by preventing abnormal blood vessel growth in the retina.

Who should consider Monoclonal Antibodies medications?

Adults

Adults with autoimmune diseases, cancers, or high-risk infections may benefit from monoclonal antibody treatments to reduce disease progression and improve survival rates. These therapies are often prescribed after other treatments, such as corticosteroids or chemotherapy, have failed or as first-line options in specific conditions.

Children

Monoclonal antibodies may be prescribed for pediatric patients with juvenile idiopathic arthritis, severe asthma, or congenital viral infections such as RSV. Dosing is carefully adjusted based on body weight, and regular monitoring ensures safety and efficacy.

Seniors

Seniors with chronic conditions, such as age-related macular degeneration or rheumatoid arthritis, may benefit from monoclonal antibodies to prevent disease progression and maintain independence. Treatment plans for seniors often involve additional monitoring due to potential drug interactions and age-related changes in kidney or liver function.

Are Monoclonal Antibodies safe?

Monoclonal antibodies are generally safe when administered as directed, but they require close monitoring due to their potential for immune-related side effects. Common side effects include mild infusion reactions, fatigue, and injection site soreness. More serious risks include anaphylaxis, cytokine release syndrome, and increased susceptibility to infections. Patients undergoing monoclonal antibody therapy typically receive premedication to prevent infusion-related reactions and regular follow-ups to monitor for complications.

Can I take Monoclonal Antibodies during pregnancy?

The safety of monoclonal antibodies during pregnancy varies depending on the medication and condition being treated. Some monoclonal antibodies, such as anti-TNF agents, may be considered safe during certain trimesters, while others, such as checkpoint inhibitors, may pose risks to fetal development. Pregnant individuals should consult their healthcare provider to weigh the risks and benefits before starting or continuing treatment.

Are Monoclonal Antibodies safe to take while lactating?

There is limited data on the safety of monoclonal antibodies during breastfeeding, though some, such as anti-TNF agents, are considered low-risk due to minimal transfer into breast milk. Patients should work with their healthcare provider to determine the safest course of action for their condition.

Are Monoclonal Antibodies controlled substances?

Monoclonal antibodies are not classified as controlled substances. However, they require a prescription and are typically administered in clinical settings under medical supervision.

Side effects of Monoclonal Antibodies?

Monoclonal antibodies are generally well-tolerated but may cause side effects. Common side effects include mild fatigue, injection site soreness, and headache. These effects are usually temporary and improve with supportive care. Less common side effects include mild allergic reactions, fever, and chills during infusions. Patients experiencing persistent symptoms should consult their healthcare provider for dose adjustments or alternative treatments. Rare but serious side effects include anaphylaxis, cytokine release syndrome, and increased risk of serious infections, such as pneumonia or sepsis. Patients experiencing these symptoms require immediate medical attention. Healthcare providers recommend regular monitoring during monoclonal antibody therapy to ensure efficacy and detect any adverse effects early.

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Cost considerations and insurance coverage for Monoclonal Antibodies

Monoclonal antibodies are often expensive due to their complex manufacturing process and clinical applications. However, most insurance plans cover monoclonal antibody treatments for approved conditions, such as cancer, autoimmune diseases, and transplant rejection. Prior authorization may be required. NiHowdy offers discounts, rebates, and Bitcoin rewards to help patients access these cutting-edge therapies affordably.

How do I get rebates on Monoclonal Antibodies?

NiHowdy's Bitcoin rebate program for monoclonal antibodies provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing chronic diseases and life-threatening conditions both affordable and rewarding, ensuring access to effective treatments while building long-term value.